Shih, Chi-Tin, Wells, Stephen A., Hsu, Ching-Ling, Cheng, Yun-Yin and Roemer, Rudolf A.. (2012) The interplay of mutations and electronic properties in disease-related genes. Scientific Reports, Vol.2 (No.272). ISSN 2045-2322

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Abstract

Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have implications for the role of the electronic properties of DNA in cellular processes, and hint at the possibility of prediction, early diagnosis and detection of mutation hotspots.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Physics Faculty of Science > Centre for Scientific Computing
Library of Congress Subject Headings (LCSH):	DNA -- Electric properties, Mutation (Biology), Medical genetics
Journal or Publication Title:	Scientific Reports
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date:	15 February 2012
Volume:	Vol.2
Number:	No.272
Identification Number:	10.1038/srep00272
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Guo jia ke xue wei yuan hui [National Science Council (Taiwan)], Leverhulme Trust (LT)
Grant number:	97-2112-M-029-002-MY3 (NSC), 100-2112-M-029-001-MY3 (NSC), F/00215/AH (LT)
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URI:	http://wrap.warwick.ac.uk/id/eprint/41953

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