The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor
Waldvogel, Eva, Herbig, Alexander, Battke, Florian, Amin, Rafat, Nentwich, Merle, Nieselt, Kay, Ellingsen, Trond E., Wentzel, Alexander, Hodgson, David A., Wohlleben, Wolfgang and Mast, Yvonne. (2011) The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor. Applied Microbiology and Biotechnology, Vol.92 (No.6). pp. 1219-1236. ISSN 0175-7598Full text not available from this repository.
Official URL: http://dx.doi.org/10.1007/s00253-011-3644-1
GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium and spore formation and loss of antibiotic production. Thus, GlnK is not only a regulator of nitrogen metabolism but also of morphological differentiation and secondary metabolite production. Through a comparative transcriptomic approach between the S. coelicolor wild-type and a S. coelicolor glnK mutant strain, 142 genes were identified that are differentially regulated in both strains. Among these are genes of the ram and rag operon, which are involved in S. coelicolor morphogenesis, as well as genes involved in gas vesicle biosynthesis and ectoine biosynthesis. Surprisingly, no relevant nitrogen genes were found to be differentially regulated, revealing that GlnK is not an important nitrogen sensor under the tested conditions.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Life Sciences (2010- )|
|Journal or Publication Title:||Applied Microbiology and Biotechnology|
|Page Range:||pp. 1219-1236|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||EU , ERA-NET SysMO , STREAM , Research Council of Norway|
|Grant number:||FP6 LSHM-CT-2004-005224 (EU) ; GEN2006-27745-E/SYS P-UK-01-11-3i (ERA-NET SysMO ) ; 181840/I30 (Research Council of Norway)|
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