Mitchell, R. M. (Rebecca M.), Medley, Graham, Collins, Michael T., 1949- and Schukken, Y. H. (Ynte H.), 1959-. (2012) A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subspecies paratuberculosis (MAP) in experimentally infected calves and cows. Epidemiology and Infection, Vol.140 (No.2). pp. 231-246. ISSN 0950-2688

Preview

PDF WRAP_Medley_S0950268811000689a.pdf - Published Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (366Kb)

Abstract

A meta-analysis was performed using all published and one unpublished long-term infection-challenge experiments to quantify the age- and dose-dependence of early and late shedding of Mycobacterium avium subsp. paratuberculosis (MAP) in cattle. There were 194 animals from 17 studies that fulfilled the inclusion criteria, of which 173 received a known dose of MAP and 21 were exposed naturally. Results from parametric time-to-event models indicated that challenging older calves or using multiple-exposure experimental systems resulted in a smaller proportion and shorter duration of early shedding as well as slower transition to late shedding from latent compartments. Calves exposed naturally showed variable infection progression rates, not dissimilar to other infection routes. The log-normal distribution was most appropriate for modelling infection-progression events. The infection pattern revealed by the modelling allowed better understanding of low-grade endemicity of MAP in cattle, and the parameter estimates are the basis for future transmission dynamics modelling.

Item Type:	Journal Article
Subjects:	S Agriculture > SF Animal culture
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Mycobacterium avium -- Mathematical models, Cattle -- Infections -- Mathematical models, Communicable diseases -- Mathematical models, Molting
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Date:	2012
Volume:	Vol.140
Number:	No.2
Number of Pages:	16
Page Range:	pp. 231-246
Identification Number:	10.1017/S0950268811000689
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), United States. Agricultural Research Service (ARS), United States. Dept. of Agriculture
Grant number:	BBS/B/04854 (BBSRC), 58-1265-3-156 (ARS), 45105 (USDA)
References:	1. Clarke CJ. The pathology and pathogenesis of paratuberculosis in ruminants and other species. Journal of Comparative Pathology 1997; 116: 217–261. 2. Whitlock RH, Buergelt C. Preclinical and clinical manifestations of paratuberculosis (including pathology). Veterinary Clinics of North America. Food Animal Practice 1996; 12: 345–356. 3. Shulaw WP, Larew-Naugle A. Paratuberculosis : a food safety concern? In: Torrence ME, Isaacson RE, eds. Microbial Food Safety in Animal Agriculture. Ames, IA: Iowa State Press, 2003. 4. Collins MT, Zhao BY. Comparison of a commercial serum antibody ELISA gamma interferon test kit, and radiometric fecal culture for early diagnosis of paratuberculosis in experimentally infected female Holstein calves. In: Chiodini RJ, Collins MT, Bassey EO, eds. Proceedings of the 4th International Colloquium on Paratuberculosis. Cambridge, UK: International Association for Paratuberculosis, 1994, pp. 67–76. 5. Stewart DJ, et al. A long-term bacteriological and immunological study in Holstein-Friesian cattle experimentally infected with Mycobacterium avium subsp. paratuberculosis and necropsy culture results for Holstein-Friesian cattle, Merino sheep and Angora goats. Veterinary Microbiology 2007; 122: 83–96. 6. Larsen AB, Merkal RS, Cutlip RC. Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis. American Journal of Veterinary Research 1975; 36: 255–257. 7. Rankin JD. The estimation of doses of Mycobacterium johnei suitable for the production of Johne’s disease in cattle. Journal of Pathology and Bacteriology 1959; 77: 638–642. 8. Medema GJ, et al. Assessment of the dose-response relationship of Campylobacter jejuni. International Journal of Food Microbiology 1996; 30: 101–111. 9. French NP, et al. Dose-response relationships for foot and mouth disease in cattle and sheep. Epidemiology and Infection 2002; 128: 325–332. 10. Windsor PA, Whittington RJ. Evidence for age susceptibility of cattle to Johne’s disease. Veterinary Journal 2010; 184: 37–44. 11. Medley GF, et al. Hepatitis-B virus endemicity: heterogeneity, catastrophic dynamics and control. Nature Medicine 2001; 7: 619–624. 12. Collins MT, et al. Consensus recommendations on diagnostic testing for the detection of paratuberculosis in cattle in the United States. Journal of the American Veterinary Medical Association 2006; 229: 1912– 1919. 13. Whitlock RH, et al. ELISA and fecal culture for paratuberculosis (Johne’s disease) : sensitivity and specificity of each method. Veterinary Microbiology 2000; 77: 387–398. 14. Larsen AB, Merkal RS, Vardaman TH. Survival time of Mycobacterium paratuberculosis. American Journal of Veterinary Research 1956; 17: 549–551. 15. Whittington RJ, et al. Survival and dormancy of Mycobacterium avium subsp. paratuberculosis in the environment. Applied and Environmental Microbiology 2004; 70: 2989–3004. 16. Mitchell RM, et al. Simulation modeling to evaluate the persistence of Mycobacterium avium subsp. paratuberculosis (MAP) on commercial dairy farms in the United States. Preventive Veterinary Medicine 2008; 83: 360–380. 17. Keeling MJ, Grenfell BT. Effect of variability in infection period on the persistence and spatial spread of infectious diseases. Mathematical Biosciences 1998; 147: 207–226. 18. Taylor AW. Experimental Johne’s disease in cattle. Journal of Comparative Pathology 1953; 63: 355–367. 19. Rankin JD. The experimental infection of cattle with Mycobacterium johnei. I. Calves inoculated intravenously. Journal of Comparative Pathology 1958; 68: 331–337. 20. Rankin JD. The experimental infection of cattle with Mycobacterium johnei. II. Adult cattle inoculated intravenously. Journal of Comparative Pathology 1961; 71: 6–9. 21. Rankin JD. The experimental infection of cattle with Mycobacterium johnei. III. Calves maintained in an infectious environment. Journal of Comparative Pathology 1961; 71: 10–15. 22. Rankin JD. The experimental infection of cattle with Mycobacterium johnei. IV. Adult cattle maintained in an infectious environment. Journal of Comparative Pathology 1962; 72: 113–117. 23. Larsen AB, Merkal RS, Moon HW. Evaluation of a paratuberculosis vaccine given to calves before infection. American Journal of Veterinary Research 1974; 35: 367–369. 24. Larsen AB, Miller JM, Merkal RS. Subcutaneous exposure of calves to Myobacterium paratuberculosis compared with intravenous and oral exposures. American Journal of Veterinary Research 1977; 38: 1669–1671. 25. Thorel MF, et al. Experimental paratuberculosis : biological diagnosis in calves inoculated with strains of mycobactin-dependent mycobacteria [in French]. Annals of Veterinary Research 1985; 16: 7–16. 26. Milner AR, et al. Analysis by ELISA and Western blotting of antibody reactivities in cattle infected with Mycobacterium paratuberculosis after absorption of serum with M phlei. Research in Veterinary Science 1987; 42: 140–144. 27. Lepper AW, et al. Sequential bacteriological observations in relation to cell-mediated and humoral antibody responses of cattle infected with Mycobacterium paratuberculosis and maintained on normal or high iron intake. Australian Veterinary Journal 1989; 66: 50–55. 28. McDonald WL, et al. Evaluation of diagnostic tests for Johne’s disease in young cattle. Australian Veterinary Journal 1999; 77: 113–119. 29. Waters WR, et al. Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calves. Infection and Immunity 2003; 71: 5130–5138. 30. Stabel JR, Palmer MV, Whitlock RH. Immune responses after oral inoculation of weanling bison or beef calves with a bison or cattle isolate of Mycobacterium avium subsp. paratuberculosis. Journal of Wildlife Diseases 2003; 39: 545–555. 31. Pollock JM, Neill SD. Mycobacterium bovis infection and tuberculosis in cattle. Veterinary Journal 2002; 163: 115–127. 32. Kao RR, et al. Mycobacterium bovis shedding patterns from experimentally infected calves and the effect of concurrent infection with bovine viral diarrhoea virus. Journal of the Royal Society, Interface 2007; 4: 545–551. 33. Cohen T, et al. Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission. Journal of the Royal Society Interface/the Royal Society 2007; 4: 523–531. 34. Rogers WH. Regression standard errors in clustered samples. Stata Technical Bulletin 1993; 13: 19–23. 35. Cleves MA, et al. Frailty Models. An introduction to survival analysis using Stata. College Station, Tex.: Stata Press, 2008, pp. 302–323. 36. Allison PD. Estimating parametric regression models with PROC LIFEREG. In: Whatley J, ed. Survival Analysis Using SAS: A Practical Guide. Cary, NC: SAS Institute, 1995, pp. 61–110. 37. Wooldridge JM. Partial likelihood methods for panel data and cluster samples. Econometric Analysis of Cross Section and Panel Data. Cambridge, MA: MIT Press, 2002, pp. 401–409. 38. Dohoo IR, Martin W, Stryhn H. Modelling survival data. In: McPike SM, ed. Veterinary Epidemiologic Research. Charlottetown, P.E.I. : AVC Inc., 2003, pp. 409–457. 39. Begg DJ, Whittington RJ. Experimental animal infection models for Johne’s disease, an infectious enteropathy caused by Mycobacterium avium subsp. paratuberculosis. Veterinary Journal 2008; 176: 129– 145. 40. Weber MF, et al. Age at which dairy cattle become Mycobacterium avium subsp. paratuberculosis faecal culture positive. Preventive Veterinary Medicine 2010; 97: 29–36. 41. van Roermund HJW, et al. Horizontal transmission of Mycobacterium avium subsp. paratuberculosis in cattle in an experimental setting : calves can transmit the infection to other calves. Veterinary Microbiology 2007; 122: 270–279. 42. Sweeney RW, et al. Isolation of Mycobacterium paratuberculosis after oral inoculation in uninfected cattle. American Journal of Veterinary Research 1992; 53: 1312–1314. 43. Groenendaal H, et al. A simulation of Johne’s disease control. Preventive Veterinary Medicine 2002; 54: 225–245. 44. Chapagain PP, et al. A mathematical model of the dynamics of Salmonella Cerro infection in a US dairy herd. Epidemiology and Infection 2008; 136: 263–272. 45. USDA. Dairy 2002 Part II : Changes in the United States Dairy Industry, 1991–2002. Fort Collins, CO: USDA: APHIS: VS, CEAH, National Animal Health Monitoring System, 2002; no. N388.0603. 46. Whitlock RH, et al. MAP Super-shedders: another factor in the control of Johne’s disease. In: Nielsen SS, ed. 8th International Colloquium on Paratuberculosis. Royal Veterinary and Agricultural University, 2005, pp. 42. 47. Dushoff J. Incorporating immunological ideas in epidemiological models. Journal of Theoretical Biology 1996; 180: 181–187. 48. Pithua P, et al. Lack of evidence for fecal shedding of Mycobacterium avium subsp. paratuberculosis in calves born to fecal culture positive dams. Preventive Veterinary Medicine 2010; 93: 242–245. 49. Collins MT, Morgan IR. Simulation model of paratuberculosis control in a dairy herd. Preventive Veterinary Medicine 1992; 14: 21–32. 246 R. M. Mitchell and others
URI:	http://wrap.warwick.ac.uk/id/eprint/42162

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item