Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity
Howson, Suzanne E., Bolhuis, Albert, Brabec, Viktor, Clarkson, Guy J., Malina, Jaroslav, Rodger, Alison and Scott, Peter, 1965 Dec. 10-. (2011) Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity. Nature Chemistry, Vol.4 (No.1). pp. 31-36. ISSN 1755-4330Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/nchem.1206
The helicates—chiral assemblies of two or more metal atoms linked by short or relatively rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices because they are of comparable size and have shown some relevant biological activity. Unfortunately, these beautiful helical compounds have remained difficult to use in the medicinal arena because they contain mixtures of isomers, cannot be optimized for specific purposes, are insoluble, or are too difficult to synthesize. Instead, we have now prepared thermodynamically stable single enantiomers of monometallic units connected by organic linkers. Our highly adaptable self-assembly approach enables the rapid preparation of ranges of water-stable, helicate-like compounds with high stereochemical purity. One such iron(II) ‘flexicate’ system exhibits specific interactions with DNA, promising antimicrobial activity against a Gram-positive bacterium (methicillin-resistant Staphylococcus aureus, MRSA252), but also, unusually, a Gram-negative bacterium (Escherichia coli, MC4100), as well as low toxicity towards a non-mammalian model organism (Caenorhabditis elegans).
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Chemistry|
|Journal or Publication Title:||Nature Chemistry|
|Publisher:||Nature Publishing Group|
|Page Range:||pp. 31-36|
|Access rights to Published version:||Restricted or Subscription Access|
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