Robson, Sam, Pukonen, Inga, Abouna, Sylvie, Pelengaris, Stella and Khan, Michael (2010) c-Myc and Downstream Targets in the Pathogenesis and Treatment of Cancer. In: Frontiers in Anti-Cancer Drug Discovery. Frontiers in Anti-Cancer Drug Discovery, Vol.1 . Netherlands: Bentham Science Publishers Ltd, pp. 340-379. ISBN 978-1-60805-161-8

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Abstract

The c-Myc oncoprotein is a master regulator of genes involved in diverse cellular processes. Situated upstream of signalling pathways regulating cellular replication/growth as well as apoptosis/growth arrest, c-Myc may help integrate processes determining cell numbers and tissue size in physiology and disease. In cancer, this ‘dual potential’ allows cMyc to act as its own tumour suppressor. Evidently, given that deregulated expression of c-myc is present in most, if not all, human cancers (Table 1) and is associated with a poor prognosis, by implication these in-built ‘failsafe’ mechanisms have been overcome. To explore the complex activity of c-Myc and its potential as a therapeutic target ‘post-genome era’ technologies for determining global gene expression alongside advanced new models for the study of tumourigenesis in vivo have proved invaluable. Thus, many recent studies have provided encouragement for the therapeutic targeting of c-Myc in cancer and have revealed new protein targets for manipulating aspects of c-Myc activity. The remarkable regression of even advanced and genetically unstable tumours, seen following deactivation of c-Myc in various models is particularly exciting. This review will discuss what is known about the role of c-Myc in growth deregulation and cancer and will conclude with a discussion of the most promising recent developments in c-Myc-targeted therapeutics.

Item Type:	Book Item
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science > Life Sciences (2010- )
Series Name:	Frontiers in Anti-Cancer Drug Discovery
Publisher:	Bentham Science Publishers Ltd
Place of Publication:	Netherlands
ISBN:	978-1-60805-161-8
Book Title:	Frontiers in Anti-Cancer Drug Discovery
Date:	2010
Volume:	Vol.1
Number of Pages:	40
Page Range:	pp. 340-379
Identification Number:	10.2174/978160805161811001010340
Status:	Not Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/42278

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