Humayun, A., Raza, Shan-e-Ahmed, Waddington, C., Abouna, Sylvie, Khan, Michael and Rajpoot, Nasir M. (Nasir Mahmood) A Novel Framework for Molecular Co-Expression Pattern Analysis in Multi-Channel Toponome Fluorescence Images. In: MIAAB 2011 (Microscopic Image Analysis with Applications in Biology), Heidelberg, Germany, Sept 2, 2011. Published in: Proceedings of the 2011 Microscopic Image Analysis with Applications in Biology (In Press)

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Abstract

Bioimage computing is rapidly emerging as an important area in image based systems biology with an emphasis on spatiotemporal localization of subcellular bio-molecules, most importantly proteins. A key problem in this domain is analysis of protein co-localization or co expression of protein molecules. Imaging techniques, such as the Toponome Imaging System (TIS) [1], with the ability to localize several different proteins in the same tissue specimen are only becoming available recently. Traditional co-localization studies and some of the modern coexpression studies have serious limitations when analyzing this kind of data. Here we present a framework for the analysis of molecular co-expression patterns (MCEPs) in TIS image data

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