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Characterization of metabolite quantitative trait loci and metabolic networks that control glucosinolate concentration in the seeds and leaves of Brassica napus
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Feng, Ji, Long, Yan, Shi, Lei, Shi, Jiaqin, Barker, Guy C. and Meng, Jinling. (2011) Characterization of metabolite quantitative trait loci and metabolic networks that control glucosinolate concentration in the seeds and leaves of Brassica napus. New Phytologist, Vol.193 (No.1). pp. 96-108. ISSN 0028-646X
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Official URL: http://dx.doi.org/10.1111/j.1469-8137.2011.03890.x
Abstract
Glucosinolates are a major class of secondary metabolites found in the Brassicaceae, whose degradation products are proving to be increasingly important for human health and in crop protection. The genetic and metabolic basis of glucosinolate accumulation was dissected through analysis of total glucosinolate concentration and its individual components in both leaves and seeds of a doubled-haploid (DH) mapping population of oilseed rape/canola (Brassica napus). The quantitative trait loci (QTL) that had an effect on glucosinolate concentration in either or both of the organs were integrated, resulting in 105 metabolite QTL (mQTL). Pairwise correlations between individual glucosinolates and prior knowledge of the metabolic pathways involved in the biosynthesis of different glucosinolates allowed us to predict the function of genes underlying the mQTL. Moreover, this information allowed us to construct an advanced metabolic network and associated epistatic interactions responsible for the glucosinolate composition in both leaves and seeds of B.similar to napus. A number of previously unknown potential regulatory relationships involved in glucosinolate synthesis were identified and this study illustrates how genetic variation can affect a biochemical pathway.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Life Sciences (2010- ) |
| Journal or Publication Title: | New Phytologist |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0028-646X |
| Date: | 2011 |
| Volume: | Vol.193 |
| Number: | No.1 |
| Number of Pages: | 13 |
| Page Range: | pp. 96-108 |
| Identification Number: | 10.1111/j.1469-8137.2011.03890.x |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | National Basic Research and Development Program (973 Program) , National 863 High Technology Program, P. R. China |
| Grant number: | 2006CB101600(973 Program), 2006AA10A113 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/42329 |
Data sourced from Thomson Reuters' Web of Knowledge
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