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An adaptive seamless phase II/III clinical trial design incorporating short-term endpoint information
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Stallard, Nigel. (2011) An adaptive seamless phase II/III clinical trial design incorporating short-term endpoint information. Trials, Vol.12 (Suppl.1). A2. ISSN 1745-6215
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Official URL: http://dx.doi.org/10.1186/1745-6215-12-S1-A2
Abstract
Adaptive seamless phase II/III designs enable a clinical trial to be conducted in stages with the most promising of a number of experimental treatments selected on the basis of data observed in the first stage to continue along with the control treatment to the second and any subsequent stages.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Clinical trials -- Design |
| Journal or Publication Title: | Trials |
| Publisher: | Bio Med Central |
| ISSN: | 1745-6215 |
| Date: | 13 December 2011 |
| Volume: | Vol.12 |
| Number: | Suppl.1 |
| Page Range: | A2 |
| Identification Number: | 10.1186/1745-6215-12-S1-A2 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access |
| Description: | Oral presentation at Clinical Trials Methodology Conference 2011, Bristol, UK. 4-5 October 2011 |
| References: | 1. Stallard N: A confirmatory seamless phase II/III clinical trial design incorporating short-term endpoint information. Statistics in Medicine 2010, 29:959-971. 2. Galbraith S, Marschner IC: Interim analysis of continuous long-term endpoints in clinical trials with longitudinal outcomes. Statistics in Medicine 2003, 22:1787-1805. 3. Jennison C, Turnbull BW: Group-sequential analysis incorporating covariate information. Journal of the American Statistical Association 1997, 92:1330-1341. 4. Stallard N, Todd S: Sequential designs for phase III clinical trials incorporating treatment selection. Statistics in Medicine 2003, 22:689-703. 5. Engel B, Walstra P: Increasing precision or reducing expense in regression experiments by using information from a concomitant variable. Biometrics 1991, 47:13-20. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/42346 |
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