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BioGlue and Peri-strips in lung volume reduction surgery : pilot randomised controlled trial

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Rathinam, Sridhar, Naidu, Babu V., Nanjaiah, Prakash, Loubani, Mahmoud, Kalkat, Maninder S. and Rajesh, Pala Babu (2009) BioGlue and Peri-strips in lung volume reduction surgery : pilot randomised controlled trial. Journal of Cardiothoracic Surgery, Vol.4 (No.1). p. 37. doi:10.1186/1749-8090-4-37

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Official URL: http://dx.doi.org/10.1186/1749-8090-4-37

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Abstract

Background
Both tissue sealants and buttressing have been advocated to reduce alveolar air leaks from staple lines following Lung Volume Reduction Surgery (LVRS). However, the long term detrimental effects of buttressing material are increasingly apparent. We performed a pilot prospective randomised self controlled trial in patients undergoing LVRS comparing BioGlue and Peri-strips as adjuncts in preventing alveolar air-leaks.

Methods
A pilot prospective self controlled clinical trial was conducted in patients undergoing LVRS. Each patient was treated with BioGlue on one side and pericardial buttress on the other side as an adjunct to the staple line. The sides were randomised for adjuncts with each patient acting as his own control. Duration of air leak, intercostal drainage and time to chest drain removal were the study end points.

Results
10 patients undergoing the procedure were recruited between December 2005 and October 2007. There were 6 men and the mean age was 59.8 ± 4.9 years. There was one mortality due to multi-organ failure. The BioGlue treated side had a shorter mean duration of air-leak (3.0 ± 4.6 versus 6.5 ± 6.9 days), lesser chest drainage volume (733 ± 404 ml versus 1001 ± 861) and shorter time to chest drain removal (9.7 ± 10.6 versus 11.5 ± 11.1 days) compared with Peri-strips.

Conclusion
This study demonstrates comparable efficacy of BioGlue and Peri-strips, however there is a trend favouring the BioGlue treated side in terms of reduction in air-leak, chest drainage volumes, duration of chest drainage and significant absence of complications. A larger sample size is needed to validate this result.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Lungs -- Surgery, Adhesives in surgery
Journal or Publication Title: Journal of Cardiothoracic Surgery
Publisher: BioMed Central Ltd.
ISSN: 1749-8090
Official Date: 17 July 2009
Dates:
DateEvent
17 July 2009Published
Volume: Vol.4
Number: No.1
Page Range: p. 37
DOI: 10.1186/1749-8090-4-37
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Cryolife Europa

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