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Cell-specific nitrogen responses mediate developmental plasticity
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Gifford, Miriam L., Dean, A., Gutierrez, R. A., Coruzzi, G. M. and Birnbaum, Kenneth D. (2008) Cell-specific nitrogen responses mediate developmental plasticity. Proceedings of the National Academy of Sciences, Vol.105 (No.2). pp. 803-808. doi:10.1073/pnas.0709559105 ISSN 0027-8424.
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Official URL: http://dx.doi.org/10.1073/pnas.0709559105
Abstract
The organs of multicellular species consist of cell types that must function together to perform specific tasks. one critical organ function is responding to internal or external change. Some cell-specific responses to changes in environmental conditions are known, but the scale of cell-specific responses within an entire organ as it perceives an environmental flux has not been well characterized in plants or any other multicellular organism. Here, we use cellular profiling of five Arabidopsis root cell types in response to an influx of a critical resource, nitrogen, to uncover a vast and predominantly cell-specific response. We show that cell-specific profiling increases sensitivity several-fold, revealing highly localized regulation of transcripts that were largely hidden from previous global analyses. The cell-specific data revealed responses that suggested a coordinated developmental response in distinct cell types or tissues. One example is the cell-specific regulation of a transcriptional circuit that we showed mediates lateral root outgrowth in response to nitrogen via microRNA167, linking small RNAs to nitrogen responses. Together, these results reveal a previously cryptic component of cell-specific responses to nitrogen. Thus, the results make an important advance in our understanding of how multicellular organisms cope with environmental change at the cell level.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > Q Science (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences | ||||
| Publisher: | National Academy of Sciences | ||||
| ISSN: | 0027-8424 | ||||
| Official Date: | 2008 | ||||
| Dates: |
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| Volume: | Vol.105 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 803-808 | ||||
| DOI: | 10.1073/pnas.0709559105 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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