Hills, Claire E. and Brunskill, Nigel J.. (2009) Cellular and physiological effects of C-peptide. Clinical Science, Vol.116 (No.7). pp. 565-574. ISSN 0143-5221

Full text not available from this repository.

Abstract

In recent years, accumulating evidence indicates a biological function for proinsulin C-peptide. These results challenge the traditional view that C-peptide is essentially inert and only useful as a surrogate marker of insulin release. Accordingly, it is now clear that C-peptide binds with high affinity to cell membranes, probably to a pertussis-toxin-sensitive G-protein-coupled receptor. Subsequently, multiple signalling pathways are potently and dose-dependently activated in multiple cell types by C-peptide with the resulting activation of gene transcription and altered cell phenotype. In diabetic animals and Type I diabetic patients, short-term studies indicate that C-peptide also enhances glucose disposal and metabolic control. Furthermore, results derived from animal models and clinical studies in Type I diabetic patients suggest a salutary effect of C-peptide in the prevention and amelioration of diabetic nephropathy and neuropathy. Therefore a picture of Type I diabetes as a dual-hormone-deficiency disease is developing, suggesting that the replacement of C-peptide alongside insulin should be considered in its management.

Item Type:	Journal Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Clinical Science
Publisher:	Portland Press
ISSN:	0143-5221
Date:	2009
Volume:	Vol.116
Number:	No.7
Number of Pages:	10
Page Range:	pp. 565-574
Identification Number:	10.1042/CS20080441
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/42600

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item