Cellular and physiological effects of C-peptide
Hills, Claire E. and Brunskill, Nigel J.. (2009) Cellular and physiological effects of C-peptide. Clinical Science, Vol.116 (No.7). pp. 565-574. ISSN 0143-5221Full text not available from this repository.
Official URL: http://dx.doi.org/10.1042/CS20080441
In recent years, accumulating evidence indicates a biological function for proinsulin C-peptide. These results challenge the traditional view that C-peptide is essentially inert and only useful as a surrogate marker of insulin release. Accordingly, it is now clear that C-peptide binds with high affinity to cell membranes, probably to a pertussis-toxin-sensitive G-protein-coupled receptor. Subsequently, multiple signalling pathways are potently and dose-dependently activated in multiple cell types by C-peptide with the resulting activation of gene transcription and altered cell phenotype. In diabetic animals and Type I diabetic patients, short-term studies indicate that C-peptide also enhances glucose disposal and metabolic control. Furthermore, results derived from animal models and clinical studies in Type I diabetic patients suggest a salutary effect of C-peptide in the prevention and amelioration of diabetic nephropathy and neuropathy. Therefore a picture of Type I diabetes as a dual-hormone-deficiency disease is developing, suggesting that the replacement of C-peptide alongside insulin should be considered in its management.
|Item Type:||Journal Article|
|Subjects:||Q Science > Q Science (General)|
|Divisions:||Faculty of Science > Life Sciences (2010- )|
|Journal or Publication Title:||Clinical Science|
|Number of Pages:||10|
|Page Range:||pp. 565-574|
|Access rights to Published version:||Restricted or Subscription Access|
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