Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A.. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. ISSN 1520-5126

Full text not available from this repository.

Abstract

Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.

Item Type:	Journal Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of the American Chemical Society
Publisher:	American Chemical Society
ISSN:	1520-5126
Official Date:	25 January 2012
Dates:	Date Event 25 January 2012 Published
Volume:	Vol.134
Number:	No.3
Number of Pages:	4
Page Range:	pp. 1454-1457
Identification Number:	10.1021/ja210496n
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust
Grant number:	REI BB/D524516/1 (BBSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/42798

Request changes or add full text files to a record

Actions (login required)

View Item