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A molecular mechanism for modulating plasma Zn speciation by fatty acids
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Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A.. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. ISSN 1520-5126
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Official URL: http://dx.doi.org/10.1021/ja210496n
Abstract
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) |
| Journal or Publication Title: | Journal of the American Chemical Society |
| Publisher: | American Chemical Society |
| ISSN: | 1520-5126 |
| Official Date: | 25 January 2012 |
| Volume: | Vol.134 |
| Number: | No.3 |
| Number of Pages: | 4 |
| Page Range: | pp. 1454-1457 |
| Identification Number: | 10.1021/ja210496n |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust |
| Grant number: | REI BB/D524516/1 (BBSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/42798 |
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