Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n

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Abstract

Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.

Item Type:	Journal Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of the American Chemical Society
Publisher:	American Chemical Society
ISSN:	1520-5126
Official Date:	25 January 2012
Dates:	Date Event 25 January 2012 Published
Volume:	Vol.134
Number:	No.3
Number of Pages:	4
Page Range:	pp. 1454-1457
DOI:	10.1021/ja210496n
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust
Grant number:	REI BB/D524516/1 (BBSRC)

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