A molecular mechanism for modulating plasma Zn speciation by fatty acids.
Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, Peter J., Pinheiro, Teresa J. T. and Blindauer, Claudia A.. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. ISSN 1520-5126Full text not available from this repository.
Official URL: http://dx.doi.org/10.1021/ja210496n
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.
|Item Type:||Journal Article|
|Subjects:||Q Science > Q Science (General)|
|Divisions:||Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
|Journal or Publication Title:||Journal of the American Chemical Society|
|Publisher:||American Chemical Society|
|Date:||25 January 2012|
|Number of Pages:||4|
|Page Range:||pp. 1454-1457|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust|
|Grant number:||REI BB/D524516/1 (BBSRC)|
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