Antibiotic resistance in the environment, with particular reference to MRSA
Gaze, William H., O'Neill, Colette, Wellington, E. M. H. and Hawkey, P. M.. (2008) Antibiotic resistance in the environment, with particular reference to MRSA. Advances in Applied Microbiology, Vol.63 . pp. 249-280. ISSN 0065-2164
WRAP_Wellington_0380313-lf-150211-antibiotic_resistance_genes_in_the_environment3.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1016/S0065-2164(07)00007-X
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine. Even before widespread global use of penicillin, resistance was already recorded. E. coli producing a penicillinase was reported in Nature in 1940 (Abraham, 1940) and soon after a similar penicillinase was discovered in Staphylococcus aureus (Kirby, 1944). The appearance of these genes, so quickly after the discovery and before the widespread introduction of penicillin, clearly shows that the resistance genes pre-dated clinical use of the antibiotic itself.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Drug resistance, Antibiotics, Bacterial genetics, Bacteriology, Agricultural, Soil microbiology, Staphylococcus aureus|
|Journal or Publication Title:||Advances in Applied Microbiology|
|Page Range:||pp. 249-280|
|Access rights to Published version:||Open Access|
Aarestrup, F. M. (2000). Characterization of glycopeptide-resistant enterococcus faecium (GRE) from broilers and pigs in Denmark: genetic evidence that persistence of GRE in pig herds is associated with coselection by resistance to macrolides. J Clin Microbiol 38, 2774-7.
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