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Methylotrophic Bacteria in Trimethylaminuria and Bacterial Vaginosis
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Wood, A. P., Warren, F. J. and Kelly, D. P. (2010) Methylotrophic Bacteria in Trimethylaminuria and Bacterial Vaginosis. In: Timmis, K.N., (ed.) Handbook of Hydrocarbon and Lipid Microbiology. Biomedical and Life Sciences , Part 29 . Heidelberg: Springer, pp. 3227-3240. ISBN 978-3-5407-7584-3
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Official URL: http://dx.doi.org/10.1007/978-3-540-77587-4_245
Abstract
The origins and metabolic transformation of trimethylamine (TMA) in the human body are summarized, and its role in pathological conditions described. The principal pathological conditions are (1) trimethylaminuria, an inherited metabolic condition preventing conversion of malodorous dietary TMA to trimethylamine-N-oxide (TMAO), (2) dimethylaminuria, a metabolic deficiency resulting in TMA production as a result of the incomplete metabolism of dietary TMA-compounds; and (3) bacterial vaginosis, characterized by excessive TMA production, principally from the microbial reduction of TMAO. Methylotrophic bacteria oxidize one-carbon compounds, such as the methylamines, as sources of energy for growth, and assimilate some of the carbon for cell biosynthesis. They are ubiquitous in nature and have themselves been implicated as opportunistic pathogens. It is proposed that methylamine-rich niches in the human body may provide significant habitats for such bacteria, and that they may have a role both in pathology and in body odor control.
| Item Type: | Book Item |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Life Sciences (2010- ) |
| Series Name: | Biomedical and Life Sciences |
| Publisher: | Springer |
| Place of Publication: | Heidelberg |
| ISBN: | 978-3-5407-7584-3 |
| Book Title: | Handbook of Hydrocarbon and Lipid Microbiology |
| Editor: | Timmis, K.N. |
| Date: | 2010 |
| Volume: | Part 29 |
| Number of Pages: | 14 |
| Page Range: | pp. 3227-3240 |
| Identification Number: | 10.1007/978-3-540-77587-4_245 |
| Status: | Not Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/43070 |
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