Tarabra, Elena, Actis, G. C., Fadda, M., De Paolis, P., Comandone, A., Coda, R. and Rosina, F.. (2012) The obesity gene and colorectal cancer risk: a population study in northern Italy. European Journal of Internal Medicine, Vol.23 (No.1). pp. 65-69. ISSN 0953-6205

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Abstract

Background: Representing the second cause of cancer-related death after lung cancer in men and breast cancer in women, colorectal cancer (CRC) is a major health problemin Italy. Obesity is reckoned to favor CRC; however, the underlying mechanisms are unclear. Recently, a single nucleotide polymorphism (SNP) in the fat mass and obesity associated (FTO) gene was found to be significantly associated with obesity. Aims: To establish whether the FTO SNP rs9939609 may represent a risk factor for CRC and adenoma in the Italian population. Patients and methods: 1,037 subjects were enrolled in the study and divided in 3 groups: CRC (341 pts., M/ F=197/144, mean age=65.17±11.16 years), colorectal adenoma (385 pts., M/F=247/138, mean age=62.49±13.01 years), healthy controls (311 pts., M/F=150/161, mean age=57.31±13.84 years). DNA was extracted from whole blood, and stored frozen for rs9939609 genotyping by real-time PCR. Results: The frequency of the obesity-associatedmutated A allele (AA+AT) on the FTO gene was 69.77% among controls, and 71.85% and 65.71% respectively among CRC and polyp patients. Compared to control subjects the AA+AT genotype had no significant effect on the risk for either CRC (OR=1.106; CI 95%=0.788–1.550; p=0.561) or colorectal adenomas (OR=0.830; CI 95%=0.602–1.144; p=0.255). We did not observe any association between the AA genotype and CRC/polyp localization and age at diagnosis. As measured in a patient subset, carriership of the risk alleles did not reflect in a significantly altered BMI. Conclusion: The obesity-linked FTO variants do not play a significant role in modulating the colorectal cancer risk in the Italian population.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	European Journal of Internal Medicine
Publisher:	Elsevier BV
ISSN:	0953-6205
Date:	January 2012
Volume:	Vol.23
Number:	No.1
Number of Pages:	5
Page Range:	pp. 65-69
Identification Number:	10.1016/j.ejim.2011.07.011
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Regione Piemonte Italy, Direzione Sanità, Ricerca Sanitaria Finalizzata
Grant number:	2472/DA2001
URI:	http://wrap.warwick.ac.uk/id/eprint/43358

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