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Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil
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Viguetti, S. Z., Pacheco, L. G. C., Santos, L. S., Soares, S. C., Bolt, F., Baldwin, Adam, Dowson, Christopher G., Rosso, M. L., Guiso, N., Miyoshi, A., Hirata, R., Mattos-Guaraldi, A. L. and Azevedo, V. (2012) Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil. Epidemiology and Infection, Volume 140 (Number 4). pp. 617-620. doi:10.1017/S0950268811000963 ISSN 0950-2688.
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WRAP_Dowson_S0950268811000963a.pdf - Published Version Download (155Kb) |
Official URL: http://dx.doi.org/10.1017/S0950268811000963
Abstract
Invasive infections caused by Corynebacterium diphtheriae in vaccinated and non-vaccinated individuals have been reported increasingly. In this study we used multilocus sequence typing (MLST) to study genetic relationships between six invasive strains of this bacterium isolated solely in the urban area of Rio de Janeiro, Brazil, during a 10-year period. Of note, all the strains rendered negative results in PCR reactions for the tox gene, and four strains presented an atypical sucrose-fermenting ability. Five strains represented new sequence types. MLST results did not support the hypothesis that invasive (sucrose-positive) strains of C. diphtheriae are part of a single clonal complex. Instead, one of the main findings of the study was that such strains can be normally found in clonal complexes with strains related to non-invasive disease. Comparative analyses with C. diphtheriae isolated in different countries provided further information on the geographical circulation of some sequence types.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Corynebacterium diphtheriae -- Genetics, Corynebacterium diphtheriae -- Brazil -- Rio de Janeiro | ||||
Journal or Publication Title: | Epidemiology and Infection | ||||
Publisher: | Cambridge University Press | ||||
ISSN: | 0950-2688 | ||||
Official Date: | April 2012 | ||||
Dates: |
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Volume: | Volume 140 | ||||
Number: | Number 4 | ||||
Page Range: | pp. 617-620 | ||||
DOI: | 10.1017/S0950268811000963 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 20 December 2015 | ||||
Date of first compliant Open Access: | 20 December 2015 | ||||
Funder: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Medical Research Council (Great Britain) (MRC), Institut Pasteur (Paris, France) |
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