Viguetti, S. Z., Pacheco, L. G. C., Santos, L. S., Soares, S. C., Bolt, F., Baldwin, Adam, Dowson, Christopher G., Rosso, M. L., Guiso, N., Miyoshi, A., Hirata, R., Mattos-Guaraldi, A. L. and Azevedo, V.. (2012) Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil. Epidemiology and Infection, Vol.140 (No.4). pp. 617-620. ISSN 0950-2688

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Abstract

Invasive infections caused by Corynebacterium diphtheriae in vaccinated and non-vaccinated individuals have been reported increasingly. In this study we used multilocus sequence typing (MLST) to study genetic relationships between six invasive strains of this bacterium isolated solely in the urban area of Rio de Janeiro, Brazil, during a 10-year period. Of note, all the strains rendered negative results in PCR reactions for the tox gene, and four strains presented an atypical sucrose-fermenting ability. Five strains represented new sequence types. MLST results did not support the hypothesis that invasive (sucrose-positive) strains of C. diphtheriae are part of a single clonal complex. Instead, one of the main findings of the study was that such strains can be normally found in clonal complexes with strains related to non-invasive disease. Comparative analyses with C. diphtheriae isolated in different countries provided further information on the geographical circulation of some sequence types.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Corynebacterium diphtheriae -- Genetics, Corynebacterium diphtheriae -- Brazil -- Rio de Janeiro
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Date:	April 2012
Volume:	Vol.140
Number:	No.4
Page Range:	pp. 617-620
Identification Number:	10.1017/S0950268811000963
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Medical Research Council (Great Britain) (MRC), Institut Pasteur (Paris, France)
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URI:	http://wrap.warwick.ac.uk/id/eprint/43436

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