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Patterns of ovarian morphology in polycystic ovary syndrome : a study utilising magnetic resonance imaging
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Barber, T. M., Alvey, Christopher, Greenslade, Tessa, Gooding, Mark, Barber, Debbie, Smith, Rachel, Marland, Anne, Wass, John A. H., Child, Tim, McCarthy, Mark I., Franks, Stephen and Golding, Stephen J. (2010) Patterns of ovarian morphology in polycystic ovary syndrome : a study utilising magnetic resonance imaging. European Radiology, Vol.20 (No.5). pp. 1207-1213. doi:10.1007/s00330-009-1643-8
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Official URL: http://dx.doi.org/10.1007/s00330-009-1643-8
Abstract
Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (n = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (n = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm3.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P = 1.3 × 10−16; calculated ovarian volume 8.8 cm3 [5.0, 15.5] vs 5.1 cm3 [2.5, 10.3], unadjusted P = 3.0 × 10–7; peripheral follicle location in 55% vs 18% of ovaries, P = 7.9 × 10–6; visible central ovarian stroma in 61% vs 24% of ovaries, P = 2.3 × 10–5). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | European Radiology | ||||
| Publisher: | Springer | ||||
| ISSN: | 0938-7994 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Vol.20 | ||||
| Number: | No.5 | ||||
| Page Range: | pp. 1207-1213 | ||||
| DOI: | 10.1007/s00330-009-1643-8 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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