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Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters

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Joharatnam, Jalini, Barber, T. M., Webber, Lisa, Conway, Gerard S., McCarthy, Mark I. and Franks, Stephen (2011) Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters. Clinical Endocrinology, Vol.74 (No.6). pp. 714-719. doi:10.1111/j.1365-2265.2011.03983.x

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1111/j.1365-2265.2011.03983.x

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Abstract

Objective  Polycystic ovary syndrome (PCOS) is associated with dyslipidaemia and obesity. It is not clear whether the dyslipidaemia of PCOS is attributable to PCOS itself, obesity, or a combination of both. Our objective was to assess the importance of familial dyslipidaemia in PCOS by comparing fasting lipids between probands and their (affected and nonaffected) sisters.

Design  Retrospective data set analyses.

Patients  Family study; 157 probands, 214 sisters and 76 control women (normal ovaries and regular cycles). All probands had PCOS, defined by symptoms of anovulation and/or hyperandrogenism with polycystic ovaries on ultrasound. Affected or unaffected status of sisters was defined by ovarian morphology.

Measurements  Serum concentrations of triglycerides, total cholesterol, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol.

Results  Triglyceride levels and body mass index (BMI) were higher and HDL cholesterol levels were lower in the probands than affected sisters, unaffected sisters and controls. These differences in lipid profiles between the groups disappeared after adjustment for BMI. No differences in lipids were seen between affected and unaffected sisters.

Conclusions  These data are consistent with heritability of lipid levels in sisters but strongly suggest that the predominant influence on the manifestation of dyslipidaemia in PCOS is body weight.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Clinical Endocrinology
Publisher: Wiley-Blackwell Publishing Ltd
ISSN: 0300-0664
Official Date: 2011
Dates:
DateEvent
2011Published
Volume: Vol.74
Number: No.6
Page Range: pp. 714-719
DOI: 10.1111/j.1365-2265.2011.03983.x
Status: Peer Reviewed
Publication Status: Published

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