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Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome
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Barber, T. M., Golding, S. J., Alvey, C., Wass, J. A. H., Karpe, F., Franks, S. and McCarthy, Mark I. (2008) Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism , Vol.93 (No.3). pp. 999-1004. doi:10.1210/jc.2007-2117
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Official URL: http://dx.doi.org/10.1210/jc.2007-2117
Abstract
Context: Obesity-related predisposition to polycystic ovary syndrome (PCOS) could reflect overall adiposity and/or regional accumulation of abdominal visceral fat.
Objective: The objective of the study was to compare distributions of visceral, abdominal sc, and gluteofemoral sc adipose tissue in PCOS cases vs. control women.
Design: This was a cross-sectional study.
Setting and Participants: Fat depot measurements from axial magnetic resonance imaging scans taken at anatomically predefined sites were compared between 22 body mass index (BMI)/fat mass-matched pairs of PCOS cases and controls; whole-group comparisons included 50 PCOS cases vs. 28 female controls. All subjects were of UK British/Irish origin.
Main Outcome Measure(s): We measured cross-sectional areas of adipose tissue within visceral (mid-L4), abdominal (mid-L4) sc, and gluteofemoral (greater trochanteric and midfemoral) sc fat depots. Other measurements included fat mass, BMI, testosterone, SHBG, and homeostasis model assessment of insulin resistance (a measure of insulin sensitivity). Whole-group analyses were adjusted for fat mass and age.
Results: There were no significant differences in fat-depot measurements between BMI/fat mass-matched pairs of PCOS cases and controls: mid-L4 visceral (P = 0.40), abdominal sc (P = 0.22), gluteal sc (P = 0.67), and midfemoral sc (P = 0.37) depots. Whole-group comparisons gave similar results after adjustments for fat mass and age. Fasting serum insulin concentrations (P = 0.03) and homeostasis model assessment of insulin resistance (P = 0.03) were significantly higher in the PCOS group than BMI/fat mass-matched controls.
Conclusions: PCOS cases and BMI/fat mass-matched control women are indistinguishable with respect to distribution of fat within visceral, abdominal sc, and gluteofemoral sc depots, despite significant differences in insulin resistance between these two groups.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Clinical Endocrinology & Metabolism | ||||
| Publisher: | Endocrine Society | ||||
| ISSN: | 0021-972x | ||||
| Official Date: | 2008 | ||||
| Dates: |
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| Volume: | Vol.93 | ||||
| Number: | No.3 | ||||
| Page Range: | pp. 999-1004 | ||||
| DOI: | 10.1210/jc.2007-2117 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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