Drover, V. A., Nguyen, D. V., Bastie, Claire C., Darlington, Y. F., Abumrad, N. A., Pessin, J. E., London, E., Sahoo, D. and Phillips, M. C.. (2008) CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. Journal of Biological Chemistry, Vol.283 (No.19). pp. 13108-13115. ISSN 0021-9258

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Abstract

The intestine has an extraordinary capacity for fatty acid (FA) absorption. Numerous candidates for a protein-mediated mechanism of dietary FA absorption have been proposed, but firm evidence for this process has remained elusive. Here we show that the scavenger receptor CD36 is required both for the uptake of very long chain FAs (VLCFAs) in cultured cells and the absorption of dietary VLCFAs in mice. We found that the fraction of CD36-dependent saturated fatty acid association/absorption in these model systems is proportional to the FA chain length and specific for fatty acids and fatty alcohols containing very long saturated acyl chains. Moreover, intestinal VLCFA absorption is completely abolished in CD36-null mice fed a high fat diet, illustrating that the predominant mechanism for VLCFA absorption is CD36-dependent. Together, these findings represent the first direct evidence for protein-facilitated FA absorption in the intestine and identify a novel therapeutic target for the treatment of diseases characterized by elevated VLCFA levels.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Biological Chemistry
Publisher:	American Society for Biochemistry and Molecular Biology
ISSN:	0021-9258
Date:	2008
Volume:	Vol.283
Number:	No.19
Page Range:	pp. 13108-13115
Identification Number:	10.1074/jbc.M708086200
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/43802

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