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Elevated striatal dopamine function linked to prodromal signs of schizophrenia
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Howes, Oliver D, Montgomery, Andrew J, Asselin, Marie-Claude, Murray, Robin M, Valli, Isabel, Tabraham, Paul, Bramon-Bosch, Elvira, Valmaggia, Lucia, Johns, Louise, Broome, Matthew R., McGuire, Philip K and Grasby, Paul M (2009) Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Archives of General Psychiatry, Vol.66 (No.1). pp. 13-20. doi:10.1001/archgenpsychiatry.2008.514 ISSN 0003-990X.
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Official URL: http://dx.doi.org/10.1001/archgenpsychiatry.2008.5...
Abstract
These findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Archives of General Psychiatry | ||||
Publisher: | American Medical Association | ||||
ISSN: | 0003-990X | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.66 | ||||
Number: | No.1 | ||||
Page Range: | pp. 13-20 | ||||
DOI: | 10.1001/archgenpsychiatry.2008.514 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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