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Elevated striatal dopamine function linked to prodromal signs of schizophrenia
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Howes, Oliver D, Montgomery, Andrew J, Asselin, Marie-Claude, Murray, Robin M, Valli, Isabel, Tabraham, Paul, Bramon-Bosch, Elvira, Valmaggia, Lucia, Johns, Louise, Broome, Matthew R., McGuire, Philip K and Grasby, Paul M. (2009) Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Archives of General Psychiatry, Vol.66 (No.1). pp. 13-20. ISSN 0003-990X
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Official URL: http://dx.doi.org/10.1001/archgenpsychiatry.2008.5...
Abstract
These findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Archives of General Psychiatry |
| Publisher: | American Medical Association |
| ISSN: | 0003-990X |
| Date: | 2009 |
| Volume: | Vol.66 |
| Number: | No.1 |
| Page Range: | pp. 13-20 |
| Identification Number: | 10.1001/archgenpsychiatry.2008.514 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/43826 |
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