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Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis
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Fusar-Poli, P, Howes, O D, Allen, P, Broome, Matthew R., Valli, I, Asselin, M-C, Montgomery, A J, Grasby, P M and McGuire, P (2011) Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Molecular Psychiatry, Vol.16 (No.1). pp. 67-75. doi:10.1038/mp.2009.108 ISSN 1359-4184.
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Official URL: http://dx.doi.org/10.1038/mp.2009.108
Abstract
Schizophrenia is characterized by altered prefrontal activity and elevated striatal dopaminergic function. To investigate the relationship between these abnormalities in the prodromal phase of the illness, we combined functional Magnetic Resonance Imaging and 18F-Dopa Positron Emission Tomography. When performing a verbal fluency task, subjects with an At-Risk Mental State showed greater activation in the inferior frontal cortex than controls. Striatal dopamine function was greater in the At-Risk group than in controls. Within the At-Risk group, but not the control group, there was a direct correlation between the degree of left inferior frontal activation and the level of striatal dopamine function. Altered prefrontal activation in subjects with an At-Risk Mental State for psychosis is related to elevated striatal dopamine function. These changes reflect an increased vulnerability to psychosis and predate the first episode of frank psychosis.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Molecular Psychiatry | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1359-4184 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.16 | ||||
Number: | No.1 | ||||
Page Range: | pp. 67-75 | ||||
DOI: | 10.1038/mp.2009.108 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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