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Abnormal frontostriatal interactions in people with prodromal signs of psychosis : a multimodal imaging study
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Fusar-Poli, P., Howes, O. D., Allen, P., Broome, Matthew R., Valli, I., Asselin, M.-C., Grasby, P. M. and McGuire, P. K. (2010) Abnormal frontostriatal interactions in people with prodromal signs of psychosis : a multimodal imaging study. Archives of General Psychiatry, Vol.67 (No.7). pp. 683-691. doi:10.1001/archgenpsychiatry.2010.77 ISSN 0003-990X.
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Official URL: http://dx.doi.org/10.1001/archgenpsychiatry.2010.7...
Abstract
Context Alterations in dopaminergic neurotransmission and function of the prefrontal cortex are thought to be central to the pathophysiology of schizophrenia, but the relationship between these factors in the development of psychosis is unclear.
Objective To investigate the relationship between striatal dopamine activity and prefrontal function in people at ultra high risk of psychosis.
Design Subjects were studied using functional magnetic resonance imaging while performing a working memory (N-back) task. Positron emission tomography with fluorine 18–labeled fluorodopa was used to investigate presynaptic striatal dopamine activity.
Setting Outpatient service for people with prodromal signs of psychosis.
Patients and Other Participants Thirty-four subjects participated in the study: 14 healthy volunteers and 20 subjects with an at-risk mental state (ARMS).
Main Outcome Measures Regional brain activation (blood oxygen level–dependent response), Ki for [18F]fluorodopa uptake, and objective ratings of psychopathology at the time of scanning.
Results In the associative part of the striatum, the Ki for [18F]fluorodopa was higher in the ARMS group than in the controls. During the N-back task, ARMS subjects displayed less activation in the right middle frontal gyrus, the medial frontal gyri, and the left superior parietal lobule than controls. The Ki for [18F]fluorodopa was positively correlated with activation in the right middle frontal gyrus in controls but negatively correlated with activation in this region in the ARMS group.
Conclusions In people with prodromal signs of psychosis, there are direct correlations between altered prefrontal cortical function and subcortical dopamine synthesis capacity, consistent with the notion that frontostriatal interactions play a critical role in the pathoetiology of schizophrenia.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Archives of General Psychiatry | ||||
Publisher: | American Medical Association | ||||
ISSN: | 0003-990X | ||||
Official Date: | July 2010 | ||||
Dates: |
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Volume: | Vol.67 | ||||
Number: | No.7 | ||||
Page Range: | pp. 683-691 | ||||
DOI: | 10.1001/archgenpsychiatry.2010.77 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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