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Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks

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Domijan, Mirela and Rand, D. A. (David A.). (2011) Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks. Interface Focus, Vol.1 (No.1). pp. 177-186. ISSN 2042-8898

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Official URL: http://dx.doi.org/10.1098/rsfs.2010.0007

Abstract

We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive. We use it to describe how an entrained clock can buffer the effects of daily fluctuations in light and temperature levels. We also use it to study a different approach to temperature compensation where instead of considering a free-running clock, we study temperature buffering of the phases in a light-entrained clock, which we believe is a more physiological setting.

Item Type:

Journal Article

Subjects:

Q Science > QA Mathematics
Q Science > QP Physiology

Divisions:

Faculty of Science > Mathematics
Faculty of Science > Centre for Systems Biology

Library of Congress Subject Headings (LCSH):

Circadian rhythms -- Mathematical models

Journal or Publication Title:

Interface Focus

Publisher:

The Royal Society Publishing

ISSN:

2042-8898

Official Date:

February 2011

Dates:

Date	Event
February 2011	Published

Volume:

Vol.1

Number:

No.1

Page Range:

pp. 177-186

Identification Number:

10.1098/rsfs.2010.0007

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU), Engineering and Physical Sciences Research Council (EPSRC)

Grant number:

BB/F005261/1 (BBSRC), 005137 (EU), EP/C544587/1 (EPSRC)

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