Domijan, Mirela and Rand, D. A. (David A.) (2011) Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks. Interface Focus, Vol.1 (No.1). pp. 177-186. doi:10.1098/rsfs.2010.0007

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Abstract

We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive. We use it to describe how an entrained clock can buffer the effects of daily fluctuations in light and temperature levels. We also use it to study a different approach to temperature compensation where instead of considering a free-running clock, we study temperature buffering of the phases in a light-entrained clock, which we believe is a more physiological setting.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics Q Science > QP Physiology
Divisions:	Faculty of Science > Mathematics Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH):	Circadian rhythms -- Mathematical models
Journal or Publication Title:	Interface Focus
Publisher:	The Royal Society Publishing
ISSN:	2042-8898
Official Date:	February 2011
Dates:	Date Event February 2011 Published
Volume:	Vol.1
Number:	No.1
Page Range:	pp. 177-186
DOI:	10.1098/rsfs.2010.0007
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU), Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	BB/F005261/1 (BBSRC), 005137 (EU), EP/C544587/1 (EPSRC)

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