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Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging
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Kershaw, Lucy E., Logue, John P., Hutchinson, Charles E., Clarke, Noel W. and Buckley, David L. (2008) Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging. Radiotherapy and Oncology, Vol.88 (No.1). pp. 127-134. doi:10.1016/j.radonc.2008.02.018 ISSN 0167-8140.
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Official URL: http://dx.doi.org/10.1016/j.radonc.2008.02.018
Abstract
Background and Purpose
To use quantitative MRI to detect changes in the vascular and MR relaxation characteristics of the prostate gland 1 year after external beam radiotherapy.
Materials and methods
Twenty-one patients underwent MRI before and after external beam radiotherapy for prostatic adenocarcinoma. Tracer kinetics analysis was applied to data from regions of interest in prostate tumour, normal prostate peripheral zone and muscle to obtain estimates of blood flow, extravascular–extracellular volume, blood volume and capillary permeability surface area product. T1 and T2 were also measured in these regions.
Results
Significant changes (p<0.05) after radiotherapy were found in all three tissues examined. Tumour blood flow was 0.34 and 0.14ml (ml tissue)−1 min−1 before and after treatment, respectively, and T1 increased from 922 to 1070ms. In normal peripheral zone, extravascular–extracellular volume increased from 0.21 to 0.52ml (ml tissue)−1, and T2 decreased from 126 to 106ms. In muscle, both permeability surface area product and T2 rose, from 0.02 to 0.06ml (ml tissue)−1 min−1 and from 50 to 56ms, respectively.
Conclusions
Quantitative MRI can be used to measure significant changes in both vascular and MR relaxation properties of the prostate and nearby muscle following treatment for prostate cancer using external beam radiotherapy.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Radiotherapy and Oncology | ||||
Publisher: | Elsevier Science BV | ||||
ISSN: | 0167-8140 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.88 | ||||
Number: | No.1 | ||||
Page Range: | pp. 127-134 | ||||
DOI: | 10.1016/j.radonc.2008.02.018 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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