Sexual activity and prostate cancer risk in men diagnosed at a younger age
Dimitropoulou, Polyxeni, Lophatananon, Artitaya, Easton, Douglas, Pocock, Richard, Dearnaley, David P., Guy, Michelle, Edwards, Steven, O’Brien, Lynne, Hall, Amanda, Wilkinson, Rosemary, Eeles, Rosalind and Muir, Kenneth (Kenneth R.). (2009) Sexual activity and prostate cancer risk in men diagnosed at a younger age. BJU International, Vol.103 (No.2). pp. 178-185. ISSN 1464-1603Full text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1464-410X.2008.08030.x
To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at ≤60 years old.
PATIENTS, SUBJECTS AND METHODS
In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants’ different age decades (20s, 30s, 40s, 50s) were collected.
Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease.
These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||BJU International|
|Publisher:||Wiley-Blackwell Publishing Ltd.|
|Page Range:||pp. 178-185|
|Access rights to Published version:||Restricted or Subscription Access|
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