. (2009) Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, Vol.41 (No.10). pp. 1116-1121. ISSN 1061-4036

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Abstract

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33).

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Nature Genetics
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Date:	2009
Volume:	Vol.41
Number:	No.10
Page Range:	pp. 1116-1121
Identification Number:	10.1038/ng.450
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/44031

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