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Dietary fat and early-onset prostate cancer risk
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Lophatananon, Artitaya, Archer, Jane, Easton, Douglas F., Pocock, Richard, Dearnaley, David P., Guy, Michelle, Kote-Jarai, Zsofia, O'Brien, Lynne T., Wilkinson, Rosemary A., Hall, Amanda L., Sawyer, Emma J., Page, Elizabeth C., Liu, Jo-Fen, Barratt, Sandra, Rahman, Aneela A., Eeles, Rosalind A. and Muir, Kenneth (2010) Dietary fat and early-onset prostate cancer risk. British Journal of Nutrition, Vol.103 (No.9). pp. 1375-1380. doi:10.1017/S0007114509993291 ISSN 0007-1145.
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Official URL: http://dx.doi.org/10.1017/S0007114509993291
Abstract
The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to prostate cancer risk. The aim of the present study was to investigate the role of dietary fat intake and its derivatives on early-onset prostate cancer risk. During 1999–2004, a population-based case–control study with 512 cases and 838 controls was conducted. Cases were diagnosed with prostate cancer when ≤ 60 years. Controls were sourced from UK GP practice registers. A self-administered FFQ collected data on typical past diet. A nutritional database was used to calculate daily fat intake. A positive, statistically significant risk estimate for the highest v. lowest quintile of intake of total fat, SFA, MUFA and PUFA was observed when adjusted for confounding variables: OR 2·53 (95 % CI 1·72, 3·74), OR 2·49 (95 % CI 1·69, 3·66), OR 2·69 (95 % CI 1·82, 3·96) and OR 2·34 (95 % CI 1·59, 3·46), respectively, with all P for trend < 0·001. In conclusion, there was a positive statistically significant association between prostate cancer risk and energy-adjusted intake of total fat and fat subtypes. These results potentially identify a modifiable risk factor for early-onset prostate cancer.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | British Journal of Nutrition | ||||
Publisher: | Cambridge University Press | ||||
ISSN: | 0007-1145 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.103 | ||||
Number: | No.9 | ||||
Page Range: | pp. 1375-1380 | ||||
DOI: | 10.1017/S0007114509993291 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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