Side-effects of antipsychotic medication and health-related quality of life in schizophrenia
Bebbington, Paul, Angermeyer, M., Azorin, J.-M., Marwaha, Steven, Marteau, F. and Toumi, M.. (2009) Side-effects of antipsychotic medication and health-related quality of life in schizophrenia. Acta Psychiatrica Scandinavica, Vol.119 (Suppl.438). pp. 22-28. ISSN 0001-690XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1600-0447.2008.01310.x
Objective: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale.
Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively.
Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS.
Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Acta Psychiatrica Scandinavica|
|Publisher:||Wiley-Blackwell Publishing, Inc.|
|Official Date:||February 2009|
|Page Range:||pp. 22-28|
|Access rights to Published version:||Restricted or Subscription Access|
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