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Side-effects of antipsychotic medication and health-related quality of life in schizophrenia
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Bebbington, Paul, Angermeyer, M., Azorin, J.-M., Marwaha, Steven, Marteau, F. and Toumi, M. (2009) Side-effects of antipsychotic medication and health-related quality of life in schizophrenia. Acta Psychiatrica Scandinavica, Vol.119 (Suppl.438). pp. 22-28. doi:10.1111/j.1600-0447.2008.01310.x ISSN 0001-690X.
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Official URL: http://dx.doi.org/10.1111/j.1600-0447.2008.01310.x
Abstract
Objective: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale.
Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively.
Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS.
Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Acta Psychiatrica Scandinavica | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISSN: | 0001-690X | ||||
| Official Date: | February 2009 | ||||
| Dates: |
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| Volume: | Vol.119 | ||||
| Number: | Suppl.438 | ||||
| Page Range: | pp. 22-28 | ||||
| DOI: | 10.1111/j.1600-0447.2008.01310.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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