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Natural selection of human embryos : impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
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Vitzthum, Virginia J., Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Macklon, Nick S. and Brosens, Jan J. (2010) Natural selection of human embryos : impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One, Vol.5 (No.4). e10287. doi:10.1371/journal.pone.0010287 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0010287
Abstract
Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cyclic differentiation of endometrial stromal cells (ESCs) into specialized decidual cells predisposes to RPL, based on the observation that this process may not only be indispensable for placenta formation in pregnancy but also for embryo recognition and selection at time of implantation.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | PLoS One | ||||
| Publisher: | Public Library of Science | ||||
| ISSN: | 1932-6203 | ||||
| Official Date: | 21 April 2010 | ||||
| Dates: |
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| Volume: | Vol.5 | ||||
| Number: | No.4 | ||||
| Page Range: | e10287 | ||||
| DOI: | 10.1371/journal.pone.0010287 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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