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Newer agents for blood glucose control in type 2 diabetes : systematic review and economic evaluation
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Waugh, Norman, Cummins, E. (Ewen), Royle, Pamela, Clar, C., Marien, M., Richter, B. and Philip, S. (2010) Newer agents for blood glucose control in type 2 diabetes : systematic review and economic evaluation. Health Technology Assessment, Vol.14 (No.36). pp. 1-248. ISSN 1366-5278.
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Official URL: http://www.hta.ac.uk/1743
Abstract
Exenatide, the gliptins and detemir were all clinically effective. The long-acting insulin analogues glargine and detemir appeared to have only slight clinical advantages over NPH, but had much higher costs and did not appear to be cost-effective as first-line insulins for type 2 diabetes. Neither did exenatide appear to be cost-effective compared with NPH but, when used as third drug after failure of dual oral combination therapy, exenatide appeared cost-effective relative to glargine in this analysis. The gliptins are similar to the glitazones in glycaemic control and costs, and appeared to have fewer long-term side effects. Therefore, it appears, as supported by recent NICE guidelines, that NPH should be the preferred first-line insulin for the treatment of type 2 diabetes. More economic analysis is required to establish when it becomes cost-effective to switch from NPH to a long-acting analogue. Also, long-term follow-up studies of exenatide and the gliptins, and data on combined insulin and exenatide treatment, would be useful.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Non-insulin-dependent diabetes -- Treatment | ||||
Journal or Publication Title: | Health Technology Assessment | ||||
Publisher: | Health Technology | ||||
ISSN: | 1366-5278 | ||||
Official Date: | July 2010 | ||||
Dates: |
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Volume: | Vol.14 | ||||
Number: | No.36 | ||||
Page Range: | pp. 1-248 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 20 December 2015 | ||||
Date of first compliant Open Access: | 20 December 2015 | ||||
Funder: | NIHR Health Technology Assessment Programme (Great Britain) | ||||
Grant number: | 08/05/01 (NIHR HTA) |
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