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Behavioural deterioration induced by intrahippocampal NAC61–95 injections and attenuation with ibuprofen
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O’Hare, Eugene, Elliott, Jennifer J., Hobson, Peter, Spanswick, David and Kim, Eun-Mee (2010) Behavioural deterioration induced by intrahippocampal NAC61–95 injections and attenuation with ibuprofen. Behavioural Brain Research, Vol.208 (No.1). pp. 274-277. doi:10.1016/j.bbr.2009.11.027 ISSN 0166-4328.
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Official URL: http://dx.doi.org/10.1016/j.bbr.2009.11.027
Abstract
Pre-aggregated non-amyloid component of α-synuclein, NAC61–95, was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n = 6 per group), subgroups were treated orally with either ibuprofen (40 mg/kg) or vehicle (10% sucrose) twice daily. Intrahippocampal injection of NAC61–95 increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Behavioural Brain Research | ||||
Publisher: | Elsevier BV | ||||
ISSN: | 0166-4328 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.208 | ||||
Number: | No.1 | ||||
Page Range: | pp. 274-277 | ||||
DOI: | 10.1016/j.bbr.2009.11.027 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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