Tildesley, Michael J., Gally, D. L., McNeilly, T. N., Low, J. C., Mahajan, A. and Savill, N. J.. (2012) Insights into mucosal innate responses to Escherichia coli O157 : H7 colonization of cattle by mathematical modelling of excretion dynamics. Journal of The Royal Society Interface, Vol.9 (No.68). pp. 518-527. ISSN 1742-5689

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Abstract

Mathematical model-based statistical inference applied to within-host dynamics of infectious diseases can help dissect complex interactions between hosts and microbes. This work has applied advances in model-based inference to understand colonization of cattle by enterohaemorrhagic Escherichia coli O157 : H7 at the terminal rectum. A mathematical model was developed based on niche replication and transition rates at this site. A nested-model comparison, applied to excretion curves from 25 calves, was used to reduce complexity while maintaining integrity. We conclude that, 5–9 days post inoculation, the innate immune response negates bacterial replication on the epithelium and either reduces attachment to or increases detachment from the epithelium of the terminal rectum. Thus, we provide a broadly applicable model that gives novel insights into bacterial replication rates in vivo and the timing and impact of host responses.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics
Divisions:	Faculty of Science > Mathematics
Journal or Publication Title:	Journal of The Royal Society Interface
Publisher:	The Royal Society Publishing
ISSN:	1742-5689
Date:	March 2012
Volume:	Vol.9
Number:	No.68
Page Range:	pp. 518-527
Identification Number:	10.1098/​rsif.2011.0293
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/44194

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