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The development of insulin resistance in Type 2 diabetes : insights from knockout studies
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Pattaranit, Ratchada, Berg, Hugo van den and Spanswick, David (2008) The development of insulin resistance in Type 2 diabetes : insights from knockout studies. Science Progress, Vol.91 (No.3). pp. 285-316. doi:10.3184/003685008X361343 ISSN 0036-8504.
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Official URL: http://dx.doi.org/10.3184/003685008X361343
Abstract
Diabetes is a common endocrine disorder, primarily characterised by elevated plasma glucose levels. The disease affects all age groups worldwide. Most patients suffer from Type 2 diabetes, which is mainly due to insulin resistance. It is thought that changes in insulin signalling pathways underlie the development of insulin resistance. This article aims to review recent studies that have elucidated the role of individual proteins in these insulin signalling pathways. These studies have been undertaken using two strategies, one employing mice carrying a global null mutation of particular gene-encoding proteins by the homologous recombination method and another strategy using mice with tissue-specific insulin receptor and/or GLUT4 knockout by the Cre-loxP system. The various phenotypes of these knockout mice, and the light they shed on the etiology of insulin resistance, are discussed. By advancing our understanding of the complex molecular mechanisms underlying insulin resistance, these knock-out models may help us to develop more effective treatments for Type 2 diabetes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QA Mathematics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Science Progress | ||||
Publisher: | Science Reviews 2000 Ltd. | ||||
ISSN: | 0036-8504 | ||||
Official Date: | September 2008 | ||||
Dates: |
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Volume: | Vol.91 | ||||
Number: | No.3 | ||||
Page Range: | pp. 285-316 | ||||
DOI: | 10.3184/003685008X361343 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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