Harte, Alison L., da Silva, Nancy F., Miller, Michelle A., Dr., Cappuccio, Francesco P., Kelly, Ann M., O'Hare, Joseph P., Barnett, Anthony H., Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Sabico, Shaun, Tripathi, Gyanendra, Bellary, Srikanth, Kumar, Sudhesh and McTernan, Philip G.. (2012) Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. Experimental Diabetes Research, Vol.2012 . p. 895185. ISSN 1687-5214

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Abstract

South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n=142) versus non-T2DM (n=76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = −0.419, P < 0.01; r = −0.443, P < 0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Library of Congress Subject Headings (LCSH):	South Asians -- Health and hygiene, Non-insulin-dependent diabetes, Aging
Journal or Publication Title:	Experimental Diabetes Research
Publisher:	Hindawi Publishing Corporation
ISSN:	1687-5214
Date:	2012
Volume:	Vol.2012
Number of Pages:	7
Page Range:	p. 895185
Identification Number:	10.1155/2012/895185
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Birmingham Science City, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, Jāmiʻat al-Malik Saʻūd. Kullīyat al-ʻUlūm [King Saud University. College of Science], King Abdulaziz City for Science and Technology (KACST)
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URI:	http://wrap.warwick.ac.uk/id/eprint/44373

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