The Library
The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
Tools
Pokhilko, Alexandra, Fernández, Aurora Piñas, Edwards, Kieron D, Southern, Megan M., Halliday, Karen J and Millar, Andrew J (2012) The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops. Molecular Systems Biology, Vol.8 . p. 574. doi:10.1038/msb.2012.6 ISSN 1744-4292.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1038/msb.2012.6
Abstract
Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can be essential for gene expression rhythms in plants. Integrating the EC components in this role significantly alters our mechanistic, mathematical model of the clock gene circuit. Negative autoregulation of the EC genes constitutes the clock's evening loop, replacing the hypothetical component Y. The EC explains our earlier conjecture that the morning gene PSEUDO-RESPONSE REGULATOR 9 was repressed by an evening gene, previously identified with TIMING OF CAB EXPRESSION1 (TOC1). Our computational analysis suggests that TOC1 is a repressor of the morning genes LATE ELONGATED HYPOCOTYL and CIRCADIAN CLOCK ASSOCIATED1 rather than an activator as first conceived. This removes the necessity for the unknown component X (or TOC1mod) from previous clock models. As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure. © 2012 EMBO and Macmillan Publishers Limited All rights reserved.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Journal or Publication Title: | Molecular Systems Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1744-4292 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
Volume: | Vol.8 | ||||
Page Range: | p. 574 | ||||
DOI: | 10.1038/msb.2012.6 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |