The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus : what do we know today?
Barber, Thomas and Franks, Stephen. (2012) The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus : what do we know today? Women's Health, Vol.8 (No.2). pp. 147-154. ISSN 1745-5057Full text not available from this repository.
Official URL: http://dx.doi.org/10.2217/whe.11.94
Polycystic ovary syndrome (PCOS) and Type 2 diabetes mellitus (T2D) are both obesity-related conditions that share epidemiological and pathophysiological factors. Insulin resistance is a key factor whereby obesity influences the expression of each condition. However, the mechanisms by which insulin resistance contributes towards the manifestation of PCOS and T2D differ in important ways: in PCOS, compensatory hyperinsulinemia results in pleiotropic effects including co-gonadotrophic stimulation of ovarian and adrenal steroidogenesis; in T2D, insulin resistance contributes towards β-cell exhaustion and ultimately to hyposecretion of insulin with resultant dysglycemia. The link between PCOS and Type 1 diabetes mellitus is believed to implicate supraphysiological concentrations of insulin within the systemic circulation. Further progression of the obesity epidemic will ensure even greater prominence of important obesity-related conditions such as PCOS and T2D. Research to gain a clearer understanding of the mechanisms linking each condition should be a priority. © 2012 Future Medicine Ltd.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Women's Health|
|Official Date:||March 2012|
|Page Range:||pp. 147-154|
|Access rights to Published version:||Restricted or Subscription Access|
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