Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Alkharfy, Khalid M., Yakout, Sobhy M., Sabico, Shaun, Gibson, Greg, Chrousos, George P. and Kumar, Sudhesh (2011) Parent-offspring transmission of adipocytokine levels and their associations with metabolic traits. PL o S One, Vol.6 (No.4). e18182 . doi:10.1371/journal.pone.0018182

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Abstract

Adipose tissue secreted cytokines (adipocytokines) have significant effects on the physiology and pathology of human
metabolism relevant to diabetes and cardiovascular disease. We determined the relationship of the pattern of these
circulating hormones with obesity-related phenotypes and whether such pattern is transmitted from parent to offspring. A
combined total of 403 individuals from 156 consenting Saudi families divided into initial (119 families with 123 adults and
131 children) and replication (37 families with 58 adults and 91 children) cohorts were randomly selected from the RIYADH
Cohort study. Anthropometrics were evaluated and metabolic measures such as fasting serum glucose, lipid profiles, insulin,
leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFa), activated plasminogen activator inhibitor 1 (aPAI1), high
sensitivity C-reactive protein (hsCRP) and angiotensin II were also assessed. Parent-offspring regressions revealed that with
the exception of hsCRP, all hormones measured showed evidence for significant inheritance. Principal component (PC)
analysis of standardized hormone levels demonstrated surprising heritability of the three most common axes of
variation. PC1, which explained 21% of the variation, was most strongly loaded on levels of leptin, TNFa, insulin, and aPAI1,
and inversely with adiponectin. It was significantly associated with body mass index (BMI) and phenotypically stronger in
children, and showed a heritability of ,50%, after adjustment for age, gender and generational effects. We conclude that
adipocytokines are highly heritable and their pattern of co-variation significantly influences BMI as early as the pre-teen
years. Investigation at the genomic scale is required to determine the variants affecting the regulation of the hormones
studied.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Heredity, Obesity -- Saudi Arabia, Cytokines, Hormones, Biochemical markers
Journal or Publication Title:	PL o S One
Publisher:	Public Library of Science
ISSN:	1932-6203
Official Date:	4 April 2011
Dates:	Date Event 4 April 2011 Published
Volume:	Vol.6
Number:	No.4
Page Range:	e18182
DOI:	10.1371/journal.pone.0018182
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	King Saud University, Riyadh, (KSA)

Data sourced from Thomson Reuters' Web of Knowledge

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