Kerr, Gary W., Sarkar, Sourav and Arumugam, Prakash (2012) How to halve ploidy : lessons from budding yeast meiosis. Cellular and Molecular Life Sciences . ISSN 1420-682X (In Press)

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Abstract

Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.

Item Type:	Submitted Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Meiosis, Gametogenesis, Saccharomyces cerevisiae
Journal or Publication Title:	Cellular and Molecular Life Sciences
Publisher:	Springer
ISSN:	1420-682X
Date:	5 April 2012
Identification Number:	10.1007/s00018-012-0974-9
Status:	Peer Reviewed
Publication Status:	In Press
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	BB/G00353X/1 (BBSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/44687

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