Programmable one-pot multistep organic synthesis using DNA junctions
McKee, Mireya L., Milnes, Phillip J., Bath, Jonathan, Stulz, Eugen, O’Reilly, Rachel K. and Turberfield, Andrew J.. (2012) Programmable one-pot multistep organic synthesis using DNA junctions. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1446-1449. ISSN 0002-7863Full text not available from this repository.
Official URL: http://dx.doi.org/10.1021/ja2101196
A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Chemistry|
|Journal or Publication Title:||Journal of the American Chemical Society|
|Publisher:||American Chemical Society|
|Official Date:||25 January 2012|
|Page Range:||pp. 1446-1449|
|Access rights to Published version:||Restricted or Subscription Access|
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