Genome-wide association analysis identifies three new breast cancer susceptibility loci
. (2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genetics, Vol.44 (No.3). pp. 312-318. ISSN 1061-4036 Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/ng.1049
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and ĝ̂1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g 35), 12q24 (rs1292011; P = 4.3 - 10 g 19) and 21q21 (rs2823093; P = 1.1 - 10 g 12). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth. © 2012 Nature America, Inc. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Nature Genetics|
|Publisher:||Nature Publishing Group|
|Page Range:||pp. 312-318|
|Access rights to Published version:||Restricted or Subscription Access|
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