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A new sighting study for the fixed concentration procedure to allow for gender differences
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Stallard, Nigel, Price, Charlotte L, Creton, Stuart, Indans, Ian, Guest, Robert, Griffiths, David and Edwards, Philippa. (2011) A new sighting study for the fixed concentration procedure to allow for gender differences. Human & Experimental Toxicology, Vol.30 (No.3). pp. 239-249. ISSN 0960-3271
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Official URL: http://dx.doi.org/10.1177/0960327110370983
Abstract
The fixed concentration procedure (FCP) has been proposed as an alternative to the median lethal
concentration (LC50) test (organisation for economic co-operation and development (OECD) test guideline
[TG] 403) for the assessment of acute inhalation toxicity. The FCP tests animals of a single gender (usually
females) at a number of fixed concentration levels in a sequential fashion. It begins with a sighting study that precedes
the main FCP study and is used to determine the main study starting concentration. In this paper, we propose
a modification to the sighting study and suggest that it should be conducted using both male and female
animals, rather than just animals of a single gender. Statistical analysis demonstrates that, when females are more
sensitive, the new procedure is likely to give the same classification as the original FCP, whereas, if males are more
sensitive, the new procedure is much less likely to lead to incorrect classification into a less toxic category. If
there is no difference in the LC50 for females and males, the new procedure is slightly more likely to classify into
a more stringent class than the original FCP. Overall, these results show that the revised sighting study ensures
gender differences in sensitivity do not significantly impact on the performance of the FCP, supporting its use as
an alternative test method for assessing acute inhalation toxicity.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Pulmonary toxicology -- Sex differences, Toxicity testing |
| Journal or Publication Title: | Human & Experimental Toxicology |
| Publisher: | Sage Publications Ltd |
| ISSN: | 0960-3271 |
| Official Date: | March 2011 |
| Volume: | Vol.30 |
| Number: | No.3 |
| Page Range: | pp. 239-249 |
| Identification Number: | 10.1177/0960327110370983 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access |
| Funder: | National Centre for the Replacement, Refinement, and Reduction of Animals in Research (Great Britain) (NC3R) |
| References: | 1. OECD.Guidelines for the testing of chemical substances. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/4501 |
Data sourced from Thomson Reuters' Web of Knowledge
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