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Carnitine in metabolic disease : potential for pharmacological intervention
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Arduini, Arduino, Bonomini, Mario, Savica, V., Amato, A and Zammit, Victor A. (2008) Carnitine in metabolic disease : potential for pharmacological intervention. Pharmacology & Therapeutics, Vol.120 (No.2). pp. 149-156. doi:10.1016/j.pharmthera.2008.08.008
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Official URL: http://dx.doi.org/10.1016/j.pharmthera.2008.08.008
Abstract
l-carnitine (LC) deficiency is commonly observed in chronic hemodialysis (HD) patients. As a result of this and other causes of secondary LC deficiencies, LC has been described as a “conditionally essential nutrient” or “conditional vitamin”. Although a large number of clinical trials regarding the beneficial effects of LC administration in HD patients have been published, some controversy about its use in this indication persists. In this article, we will review the use of LC in dialysis patients, by focussing mainly on those experimental and clinical data supporting the notion that supra-physiological concentrations of LC in plasma and target organs may exert beneficial effects on several metabolic parameters that have derangements of a common origin (e.g. insulin resistance, type 2 diabetes, dyslipidemia) and which are frequently present in end-stage renal disease (ESRD) patients undergoing dialysis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Pharmacology & Therapeutics | ||||
| Publisher: | Elsevier Inc. | ||||
| ISSN: | 0163-7258 | ||||
| Official Date: | November 2008 | ||||
| Dates: |
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| Volume: | Vol.120 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 149-156 | ||||
| DOI: | 10.1016/j.pharmthera.2008.08.008 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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