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Compromised chorionic villous vascularization in idiopathic second trimester fetal loss
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van Oppenraaij, R.H.F., Nik, H., Heathcote, L., McPartland, J.L., Turner, M.A., Quenby, Siobhan, Steegers, E.A.P. and Exalto, N. (2010) Compromised chorionic villous vascularization in idiopathic second trimester fetal loss. Early Human Development, Vol.86 (No.8). pp. 469-472. doi:10.1016/j.earlhumdev.2010.06.005 ISSN 0378-3782 .
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Official URL: http://dx.doi.org/10.1016/j.earlhumdev.2010.06.005
Abstract
Background
For normal fetal growth and development a well-developed chorionic villous vascularization is essential.
Aim
The aim of this study is to investigate whether idiopathic second trimester fetal loss is associated with an underdeveloped chorionic villous vascularization.
Methods
38 placentas after late miscarriage, classified as idiopathic fetal loss (IFL, n = 16) or as fetal loss due to intrauterine infection (IUI, n = 22) were collected. After CD34 immunohistochemical staining the villous stromal area, number of villous vessels, vascular area and vascular area density (central, peripheral and total) were measured in randomly selected immature intermediate villi.
Results
The mean gestational age was 19 + 4 weeks for the IFL group and 20 + 6 weeks for the IUI group. After controlling for gestational age, we found no differences in fetal weight, placental weight, villous stromal area, number of vessels and central vascular features. The mean peripheral vascular area and peripheral vascular area density were, after adjusting for gestational age, reduced in the IFL group.
Conclusion
Idiopathic second trimester fetal loss is associated with a reduced peripheral chorionic villous vascularization. We hypothesize that in these cases, placentation is already disturbed in first trimester of pregnancy, leading to a reduced materno–fetal interface in second trimester, thus to early postplacental fetal hypoxia and fetal death.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Early Human Development | ||||
Publisher: | Elsevier Ireland Ltd | ||||
ISSN: | 0378-3782 | ||||
Official Date: | August 2010 | ||||
Dates: |
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Volume: | Vol.86 | ||||
Number: | No.8 | ||||
Page Range: | pp. 469-472 | ||||
DOI: | 10.1016/j.earlhumdev.2010.06.005 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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