Riddell, Carolyn, Adams, Sally, Schmid-Hempel, Paul and Mallon, Eamonn B.. (2009) Differential expression of immune defences is associated with specific host-parasite interactions in insects. PL o S One, Vol.4 (No.10). ISSN 1932-6203

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Abstract

Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broadspectrum recognition system. An important question is whether this specificity is due to the immune response rather than some other interplay between host and parasite genotypes. By measuring the expression of putative bumblebee homologues of antimicrobial peptides in response to infection by their gut trypanosome Crithidia bombi, we demonstrate that expression differences are associated with the specific interactions.

Item Type:	Journal Article
Subjects:	Q Science > QL Zoology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Host-parasite relationships, Invertebrates -- Infections, Immune response, Bumblebees -- Infections, Crithidia
Journal or Publication Title:	PL o S One
Publisher:	Public Library of Science
ISSN:	1932-6203
Date:	27 October 2009
Volume:	Vol.4
Number:	No.10
Identification Number:	10.1371/journal.pone.0007621
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), British Ecological Society
References:	1. Schmid-Hempel P, Ebert D (2003) On the evolutionary ecology of specific immune defence. Trends in Ecology and Evolution 18: 27–32. 2. Gillespie JP, Kanost MR, Trenczek T (1997) Biological mediators of insect immunity. Annual Review of Entomology 42: 611–643. 3. Du Pasquier L (2005) Insects diversify one molecule to serve two systems. Science 309: 1826–1827. 4. Hauton C, Smith VJ (2007) Adaptive immunity in invertebrates: a straw house without a mechanistic foundation. Bioessays 29: 1138–1146. 5. Schmid-Hempel P (2005) Natural insect host-parasite systems show immune priming and specificity: puzzles to be solved. Bioessays 27: 1026–1034. 6. Schmid-Hempel P, Reber-Funk C (2004) The distribution of genotypes of the trypanosome parasite, Crithidia bombi, in populations of its host Bombus terrestris. Parasitology 129: 147–158. 7. Boulanger N, Bulet P, Lowenberger C (2006) Antimicrobial peptides in the interactions between insects and flagellate parasites. Trends in Parasitology 22: 262–268. 8. Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLOS Pathogens 2: 551–561. 9. Ryu JH, Ha EM, Oh CT, Seol JH, TBrey P, et al. (2006) An essential complementary role of NF-kappa B pathway to microbicidal oxidants in Drosophila gut immunity. Embo Journal 25: 3693–3701. 10. Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, et al. (2000) Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13: 737–748. 11. Boulanger N, Lowenberger C, Volf P, Ursic R, Sigutova L, et al. (2004) Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major. Infection and Immunity 72: 7140–7146. 12. Boulanger N, Brun R, Ehret-Sabatier L, Kunz C, Bulet P (2002) Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections. Insect Biochemistry and Molecular Biology 32: 369–375. 13. Boulanger N, Ehret-Sabatier L, Brun R, Zachary D, Bulet P, et al. (2001) Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp. Insect Biochemistry and Molecular Biology 31: 129–137. 14. Schmid-Hempel P, Puhr K, Kruger N, Reber C, Schmid-Hempel R (1999) Dynamic and genetic consequences of variation in horizontal transmission for a microparasitic infection. Evolution 53: 426–434. 15. Evans JD, Pettis JS (2005) Colony-level impacts of immune responsiveness in honey bees, Apis mellifera. Evolution 59: 2270–2274. 16. Siva-Jothy MT, Moret Y, Rolff J (2005) Insect immunity: An evolutionary ecology perspective. Advances in Insect Physiology 32: 1–48. 17. Rutschmann S, Kilinc A, Ferrandon D (2002) Cutting edge: The Toll pathway is required for resistance to Gram-positive bacterial infections in Drosophila. Journal of Immunology 168: 1542–1546. 18. Schluns H, Crozier RH (2007) Relish regulates expression of antimicrobial peptide genes in the honeybee, Apis mellifera, shown by RNA interference. Insect molecular biology 16: 753–759. 19. Watson FL, Puttmann-Holgado R, Thomas F, Lamar DL, Hughes M, et al. (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309: 1874–1878. 20. Zhang SM, Loker ES (2004) Representation of an immune responsive gene family encoding fibrinogen-related proteins in the freshwater mollusc Biomphalaria glabrata, an intermediate host for Schistosoma mansoni. Gene 341: 255–266. 21. Wang XG, Zhao Q, Christensen BM (2005) Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. BMC Genomics 6: 114.
URI:	http://wrap.warwick.ac.uk/id/eprint/4538

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