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Denosumab for the prevention of osteoporotic fractures in postmenopausal women
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Waugh, Norman, Royle, Pamela, Scotland, Graham, Henderson, Rob, Hollick, Rosemary and McNamee, Paul. (2011) Denosumab for the prevention of osteoporotic fractures in postmenopausal women. Health Technology Assessment, Vol.15 (No.S1). pp. 51-59. ISSN 1366-5278
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Official URL: http://dx.doi.org/10.3310/hta15suppl01/06
Abstract
This paper presents a summary of the evidence review group (ERG) report into denosumab for the prevention of osteoporotic fractures in postmenopausal women. Denosumab has been shown in a large randomised trial to reduce the frequency of osteoporotic fractures when given subcutaneously at 6-monthly intervals. Compared with placebo, the relative risks of clinical vertebral and hip fractures were 0.32 and 0.60, respectively. Clinical vertebral fractures occurred in 0.8% of women taking denosumab and 2.6% of control subjects. Hip fractures occurred in 1.2% of women on placebo and 0.7% on denosumab. The expected use is in women who cannot tolerate oral bisphosphonates. Other options in that situation include strontium ranelate and zoledronate, which, compared with placebo, also reduced the risk of clinical vertebral fractures [relative risk (RR) 0.65 and 0.23, respectively]. Zoledronate also significantly reduced the risk of hip fractures (RR 0.59). The ERG concluded that zoledronate was the main comparator. The relative cost-effectiveness of denosumab and zoledronate depends mainly on assumptions about costs of administration.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences |
| Library of Congress Subject Headings (LCSH): | Osteoporosis -- Treatment, Fractures -- Treatment |
| Journal or Publication Title: | Health Technology Assessment |
| Publisher: | NIHR Health Technology Assessment programme |
| ISSN: | 1366-5278 |
| Date: | 2011 |
| Volume: | Vol.15 |
| Number: | No.S1 |
| Page Range: | pp. 51-59 |
| Identification Number: | 10.3310/hta15suppl01/06 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | NIHR Health Technology Assessment Programme (Great Britain) |
| Grant number: | 08/231/01 (NIHR) |
| Version or Related Resource: | Scotland, G., et al. (2010) Evidence review : denosumab for the prevention of osteoporotic fractures in post-menopausal women. [Report] ; Scotland, G., et al. (2011) Denosumab for the prevention of osteoporotic fractures in post-menopausal women. PharmacoEconomics, Vol.29 (No.11). pp. 951-961 |
| Related URLs: | |
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| URI: | http://wrap.warwick.ac.uk/id/eprint/45413 |
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