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Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices
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Lewandowski, Krzysztof C., Nadel, Iwona, Lewinski, Andrzej, Bienkiewicz, Malgorzata, Tan, Bee K., Randeva, Harpal S. and Cypryk, Katarzyna (2010) Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices. Ginekologia Polska, Vol.81 (No.12). pp. 907-912. ISSN 0017-0011.
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Abstract
Gestational Diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression.
Subjects and Methods: The study included 20 women with GDM, diagnosed according to the WHO criteria, and 23 matched for age and BMI women with normal glucose tolerance. Omentin and TSP-1 were measured by ELISA assays. Insulin resistance was assessed by NOMA and Insulin Resistance Index (IRI).
Results: There were no significant differences in omen tin and TSP-1 levels between subjects with GDM and controls (48.0 +/- 12.0ng/ml versus 50.2 +/- 7.9ng/ml and 2150 +/- 1661ng/ml versus 1569 +/- 1160ng/ml, p=0.64 and p=0.29, for omentin and TSP-1 in GDM and control subjects, respectively). There was no significant correlation between either omen tin or TSP-1 with HOMA or IRI, however there was a significant positive correlation between thrombospondin-1 and omentin (r=0.49, p=0.010). There was also a positive correlation between serum omentin and glucose levels at 60 and 90 minutes of OGTT, however in the control group only (p<0.05).
Conclusions: Concentrations of omen tin and thrombospondin-1 seem to be inter-related in pregnancy however there are no differences in serum levels between women with normal glucose tolerance and those with glucose intolerance. These observations suggest that regulation of concentrations of these adipokines in pregnancy might be mediated though different mechanisms than in non-pregnant subjects.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Ginekologia Polska | ||||
Publisher: | Polskie Towarzystwo Ginekologiczne | ||||
ISSN: | 0017-0011 | ||||
Official Date: | December 2010 | ||||
Dates: |
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Volume: | Vol.81 | ||||
Number: | No.12 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 907-912 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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