Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression
Browning, Douglas F., Grainger, David C. and Busby, Stephen J. W. (2010) Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression. Current Opinion in Microbiology, Volume 13 (Number 6). pp. 773-780. ISSN 1369-5274Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.mib.2010.09.013
Bacterial nucleoid-associated proteins play a key role in the organisation, replication, segregation, repair and expression of bacterial chromosomes. Here, we review some recent progress in our understanding of the effects of these proteins on DNA and their biological role, focussing mainly on Escherichia coli and its chromosome. Certain nucleoid-associated proteins also regulate transcription initiation at specific promoters, and work in concert with dedicated transcription factors to regulate gene expression in response to growth phase and environmental change. Some specific examples, involving the E. coli IHF and Fis proteins, that illustrate new principles, are described in detail.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Gene expression, Bacterial chromosomes, Nucleoids, Proteins|
|Journal or Publication Title:||Current Opinion in Microbiology|
|Official Date:||December 2010|
|Number of Pages:||8|
|Page Range:||pp. 773-780|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Wellcome Trust (London, England)|
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