The growth restriction intervention trial : long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction
Walker, Dawn-Marie, Marlow, Neil, Upstone, Lisa, Gross, Harriet, Dr., Hornbuckle, Janet, Vail, Andy, Wolke, Dieter and Thornton, Jim (Jim G.). (2011) The growth restriction intervention trial : long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. American Journal of Obstetrics and Gynecology, Vol.204 (No.1). 34.e1-34.e9. ISSN 0002-9378Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ajog.2010.09.019
OBJECTIVE: The Growth Restriction Intervention Trial found little difference in overall mortality or 2-year outcomes associated with immediate or deferred delivery following signs of impaired fetal health in the presence of growth restriction when the obstetrician was unsure whether to deliver. Because early childhood assessments have limited predictive value, we reevaluated them.
STUDY DESIGN: Children were tested with standardized school-based evaluations of cognition, language, motor performance, and behavior. Analysis and interpretation were Bayesian.
RESULTS: Of 376 babies, 302 (80%) had known outcome: either dead or evaluated at age 6-13 years. Numbers of children dead, or with severe disability: 21 (14%) immediate and 25 (17%) deferred groups. Among survivors, the mean (SD) cognition scores were 95 (15) and 96 (14); motor scores were 8.9 (7.0) and 8.7 (6.7); and parent-assessed behavior scores were 10.5 (7.1) and 10.5 (6.9), respectively, for the 2 groups.
CONCLUSION: Clinically significant differences between immediate and deferred delivery were not found.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science > Psychology
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Fetal growth disorders, Cognition in children -- Research, Neuropsychology, Premature infants -- Development, Premature infants -- Death, Fetal growth retardation|
|Journal or Publication Title:||American Journal of Obstetrics and Gynecology|
|Official Date:||January 2011|
|Number of Pages:||9|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Medical Research Council (Great Britain) (MRC)|
|Version or Related Resource:||Presented at: 56th Annual Scientific Meeting of the Society of Gynecological Investigation, Glasgow UK, 18-21 Mar 2009|
|Conference Paper Type:||Paper|
|Type of Event:||Conference|
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