Walker, Dawn-Marie, Marlow, Neil, Upstone, Lisa, Gross, Harriet, Dr., Hornbuckle, Janet, Vail, Andy, Wolke, Dieter and Thornton, Jim (Jim G.). (2011) The growth restriction intervention trial : long-term outcomes in a randomized trial of timing of delivery in fetal growth restriction. American Journal of Obstetrics and Gynecology, Vol.204 (No.1). 34.e1-34.e9. ISSN 0002-9378

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Abstract

OBJECTIVE: The Growth Restriction Intervention Trial found little difference in overall mortality or 2-year outcomes associated with immediate or deferred delivery following signs of impaired fetal health in the presence of growth restriction when the obstetrician was unsure whether to deliver. Because early childhood assessments have limited predictive value, we reevaluated them. STUDY DESIGN: Children were tested with standardized school-based evaluations of cognition, language, motor performance, and behavior. Analysis and interpretation were Bayesian. RESULTS: Of 376 babies, 302 (80%) had known outcome: either dead or evaluated at age 6-13 years. Numbers of children dead, or with severe disability: 21 (14%) immediate and 25 (17%) deferred groups. Among survivors, the mean (SD) cognition scores were 95 (15) and 96 (14); motor scores were 8.9 (7.0) and 8.7 (6.7); and parent-assessed behavior scores were 10.5 (7.1) and 10.5 (6.9), respectively, for the 2 groups. CONCLUSION: Clinically significant differences between immediate and deferred delivery were not found.

Item Type:	Journal Article
Subjects:	R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH):	Fetal growth disorders, Cognition in children -- Research, Neuropsychology, Premature infants -- Development, Premature infants -- Death, Fetal growth retardation
Journal or Publication Title:	American Journal of Obstetrics and Gynecology
Publisher:	Mosby-Elsevier
ISSN:	0002-9378
Date:	January 2011
Volume:	Vol.204
Number:	No.1
Number of Pages:	9
Page Range:	34.e1-34.e9
Identification Number:	10.1016/j.ajog.2010.09.019
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council (Great Britain) (MRC)
Version or Related Resource:	Presented at: 56th Annual Scientific Meeting of the Society of Gynecological Investigation, Glasgow UK, 18-21 Mar 2009
Conference Paper Type:	Paper
Type of Event:	Conference
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URI:	http://wrap.warwick.ac.uk/id/eprint/4569

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