FOXO transcription factors and their role in disorders of the female reproductive tract
Christian, Mark, Lam, E. W. -F., Wilson, Miranda S. C. and Brosens, Jan J.. (2011) FOXO transcription factors and their role in disorders of the female reproductive tract. Current Drug Targets, Vol.12 (No.9). pp. 1291-1302. ISSN 1389-4501Full text not available from this repository.
Official URL: http://www.bentham.org/cdt
All fundamental reproductive events in the human ovary and uterus, including ovulation, implantation and menstruation, are dependent upon profound tissue remodelling, characterized by cyclical waves of cell proliferation, differentiation, recruitment of inflammatory cells, apoptosis, tissue breakdown and regeneration. Although the rise and fall in ovarian hormones, estradiol and progesterone, orchestrate these reproductive events, FOXO transcription factors, an evolutionary conserved subfamily of forkhead transcription factors, have emerged major downstream effector molecules, capable of integrating hormonal cues with a variety of stress, growth factor and cytokine signal transduction pathways. The ability of FOXOs to regulate seemingly opposing cellular responses, ranging from cell cycle arrest and oxidative stress responses to differentiation and apoptosis, renders these transcription factors indispensable for cyclic tissue remodelling in the reproductive tract. Aberrant expression or perturbed activity of FOXO transcription factors are increasingly linked to prevalent reproductive disorders, such as endometriosis, endometrial cancer, primary ovarian insufficiency and pregnancy failure, which in turn highlights their potential as therapeutic targets.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Current Drug Targets|
|Publisher:||Bentham Science Publishers Ltd.|
|Official Date:||August 2011|
|Number of Pages:||12|
|Page Range:||pp. 1291-1302|
|Access rights to Published version:||Restricted or Subscription Access|
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